The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy.

  title={The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy.},
  author={Emilie Vazeille and Audrey Codran and Agn{\`e}s Claustre and Julien Averous and Anne Listrat and Daniel B{\'e}chet and Daniel Taillandier and Dominique Dardevet and Didier Attaix and Lydie Combaret},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={295 5},
Immobilization produces morphological, physiological, and biochemical alterations in skeletal muscle leading to muscle atrophy and long periods of recovery. Muscle atrophy during disuse results from an imbalance between protein synthesis and proteolysis but also between apoptosis and regeneration processes. This work aimed to characterize the mechanisms underlying muscle atrophy and recovery following immobilization by studying the regulation of the mitochondria-associated apoptotic and the… 

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