The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.

@article{Tsuchida2010TheUL,
  title={The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.},
  author={Tetsuo Tsuchida and Jian Zou and Tatsuya Saitoh and Himanshu Kumar and Takayuki Abe and Yoshiharu Matsuura and Taro Kawai and Shizuo Akira},
  journal={Immunity},
  year={2010},
  volume={33 5},
  pages={765-76}
}
The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified interferon-inducible tripartite-motif (TRIM) 56 as a regulator of double-stranded DNA-mediated type I interferon induction. TRIM56 overexpression enhanced IFN-β promoter… CONTINUE READING