The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways.

@article{Qi2008TheUL,
  title={The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways.},
  author={Jianfei Qi and Koh Nakayama and Supriya Gaitonde and James S Goydos and Stan Stanislaw Krajewski and A. M. Eroshkin and Dafna Bar-Sagi and David Bowtell and Ze'ev A Ronai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 43},
  pages={16713-8}
}
The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability with concomitant effect on HIF-1alpha availability. Because HIF-1alpha is implicated in tumorigenesis and metastasis, we used SW1 mouse melanoma cells, which develop primary tumors with a propensity to metastasize, in a syngeneic mouse model to assess a possible role for Siah2 in these processes. Inhibiting Siah2 activity by expressing a peptide designed to outcompete association of Siah2-interacting… CONTINUE READING

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