The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.

@article{Holland2011TheUL,
  title={The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.},
  author={Sabrina Holland and Ovidiu Coste and Dong Dong Zhang and Sandra C. Pierre and Gerd 7 Geisslinger and Klaus Scholich},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 5},
  pages={3671-80}
}
The E3 ubiquitin ligase MYCBP2 negatively regulates neuronal growth, synaptogenesis, and synaptic strength. More recently it was shown that MYCBP2 is also involved in receptor and ion channel internalization. We found that mice with a MYCBP2-deficiency in peripheral sensory neurons show prolonged thermal hyperalgesia. Loss of MYCBP2 constitutively activated… CONTINUE READING