The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.

@article{Roest2004TheUD,
  title={The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.},
  author={Henk P. Roest and Willy M Baarends and Jan de Wit and Jan W van Klaveren and Evelyne Wassenaar and Jos W. Hoogerbrugge and Wiggert A van Cappellen and Jan H. J. Hoeijmakers and J. Anton Grootegoed},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 12},
  pages={5485-95}
}
The Saccharomyces cerevisiae RAD6 protein is required for a surprising diversity of cellular processes, including sporulation and replicational damage bypass of DNA lesions. In mammals, two RAD6-related genes, HR6A and HR6B, encode highly homologous proteins. Here, we describe the phenotype of cells and mice deficient for the mHR6A gene. Just like mHR6B knockout mouse embryonic fibroblasts, mHR6A-deficient cells appear to have normal DNA damage resistance properties, but mHR6A knockout male and… CONTINUE READING

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