The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

@article{Huang2015TheU,
  title={The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.},
  author={Guochang Huang and Christopher W Towe and Lydia Choi and Yoshihiro Yonekawa and Claire C. Bommelj{\'e} and Sarina Bains and Willi Rechler and Bing Hao and Yegnanarayana Ramanathan and Bhuvanesh Singh},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 1},
  pages={
          296-309
        }
}
Amplification of squamous cell carcinoma-related oncogene (SCCRO) activates its function as an oncogene in a wide range of human cancers. The oncogenic activity of SCCRO requires its potentiating neddylation domain, which regulates its E3 activity for neddylation. The contribution of the N-terminal ubiquitin-associated (UBA) domain to SCCRO function remains to be defined. We found that the UBA domain of SCCRO preferentially binds to polyubiquitin chains in a linkage-independent manner. Binding… CONTINUE READING
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