The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.

@article{Roln2009TheUC,
  title={The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.},
  author={Ulrika Rol{\'e}n and Elio Freda and Jianjun Xie and Thorsten Pfirrmann and Teresa Frisan and Maria G Masucci},
  journal={Journal of cellular and molecular medicine},
  year={2009},
  volume={13 8B},
  pages={1666-78}
}
The ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts. UCH-L1 has been detected in a variety of malignant and metastatic tumours but its biological function in these cells is unknown. We have previously shown that UCH-L1 is highly expressed in Burkitt's lymphoma (BL) and is up-regulated upon infection of B lymphocytes with Epstein-Barr virus (EBV). Here we show that knockdown of UCH-L1 by… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…