The ubiquitin C-terminal hydrolase UCH-L1 promotes bacterial invasion by altering the dynamics of the actin cytoskeleton.

@article{Bassres2010TheUC,
  title={The ubiquitin C-terminal hydrolase UCH-L1 promotes bacterial invasion by altering the dynamics of the actin cytoskeleton.},
  author={Eug{\'e}nie Bass{\`e}res and Giuseppe Coppotelli and Thorsten Pfirrmann and Jens Bo Andersen and Maria G Masucci and Teresa Frisan},
  journal={Cellular microbiology},
  year={2010},
  volume={12 11},
  pages={
          1622-33
        }
}
Invasion of eukaryotic target cells by pathogenic bacteria requires extensive remodelling of the membrane and actin cytoskeleton. Here we show that the remodelling process is regulated by the ubiquitin C-terminal hydrolase UCH-L1 that promotes the invasion of epithelial cells by Listeria monocytogenes and Salmonella enterica. Knockdown of UCH-L1 reduced the uptake of both bacteria, while expression of the catalytically active enzyme promoted efficient internalization in the UCH-L1-negative HeLa… CONTINUE READING
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