The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.

@article{Carter1999TheTP,
  title={The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.},
  author={Jeffrey D Carter and Benjamin G Neel and Ulrike M Lorenz},
  journal={International immunology},
  year={1999},
  volume={11 12},
  pages={
          1999-2014
        }
}
Modulation of the strength of signals from the TCR determines the outcome of positive and negative selection in thymocyte development. Previous studies have demonstrated that SHP-1 plays a role in determining signal strength from the TCR. Here, we have taken a genetic approach to test whether SHP-1 plays a role in T cell selection in the thymus. Experiments in which a dominant negative mutant of SHP-1 was expressed in the BYDP hybridoma cell line confirmed that SHP-1 regulated TCR signaling in… CONTINUE READING
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