The tyrosine phosphatase Ptpn22 discriminates weak, self-peptide from strong agonist T cell receptor signals

@inproceedings{Salmond2014TheTP,
  title={The tyrosine phosphatase Ptpn22 discriminates weak, self-peptide from strong agonist T cell receptor signals},
  author={Robert J Salmond and Rebecca J Brownlie and Vicky Louise Morrison and Rose Zamoyska},
  booktitle={Nature Immunology},
  year={2014}
}
T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens to provide protection against infection. We found that in both naive T cells and effector T cells, the tyrosine phosphatase PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens. T cells lacking PTPN22 showed enhanced formation of conjugates with antigen-presenting cells pulsed with weak peptides… CONTINUE READING
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