The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

@inproceedings{Asbagh2014TheTP,
  title={The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling},
  author={Layka Abbasi Asbagh and Iria V{\'a}zquez and Loredana Vecchione and Eva Budinska and Veerle De Vriendt and Maria Francesca Baietti and Mikhail Steklov and Bart Jacobs and Nicholas Hoe and Sharat Singh and Naga-Sailaja Imjeti and Pascale Zimmermann and Anna A. Sablina and Sabine Tejpar},
  booktitle={Oncotarget},
  year={2014}
}
Inappropriate activation of epidermal growth factor receptor (EGFR) plays a causal role in many cancers including colon cancer. The activation of EGFR by phosphorylation is balanced by receptor kinase and protein tyrosine phosphatase activities. However, the mechanisms of negative EGFR regulation by tyrosine phosphatases remain largely unexplored. Our… CONTINUE READING