The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated APOBEC3G into vif-defective HIV-1 particles.

@article{Douaisi2005TheTK,
  title={The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated APOBEC3G into vif-defective HIV-1 particles.},
  author={Marc P. Douaisi and Sylvie Dussart and Marianne Courcoul and Gilles Bessou and Edwina C. Lerner and Etienne Decroly and Robert Vigne},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={329 3},
  pages={917-24}
}
The main function of Vif is to limit the antiviral activity of APOBEC3G by counteracting its packaging into HIV-1 virions. In this work, we examine the possible functional interactions between Vif, APOBEC3G, and two Src family tyrosine kinases, Fyn and Hck, present in T lymphocytes and in monocyte-macrophages, respectively. By GST pull-down, we show that the SH3 domains of Fyn and Hck, and the corresponding full-length proteins bind Vif of HIV-1. One consequence of this interaction is a… CONTINUE READING

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