The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model

@article{Sandstrm2004TheTK,
  title={The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model},
  author={Maria Sandstr{\"o}m and M Johansson and U. Andersson and Anders Bergh and A. Tommy Bergenheim and Roger Henriksson},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={1174 - 1180}
}
Malignant glioma is characterised by extensive neovascularisation, principally influenced by vascular endothelial growth factor (VEGF). ZD6474 is a potent inhibitor of VEGF-R2 tyrosine kinase activity, but with additional inhibitory effects on other growth factors. In this study, we have investigated the effects of ZD6474 with regard to tumour growth… CONTINUE READING