The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells.

@article{Gao2006TheTK,
  title={The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells.},
  author={Beixue Gao and Sang-Myeong Lee and Deyu Fang},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 40},
  pages={29711-8}
}
The cross-talk of ubiquitination with other types of posttranscriptional modifications, such as phosphorylation, regulates the stability of many proteins. We have previously demonstrated that c-Jun is a substrate of Itch, a HECT-type E3 ubiquitin ligase. c-Jun is also a substrate of the tyrosine kinase c-Abl. Here we report that genetic ablation of c-Abl… CONTINUE READING