The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria.

@article{Mendes2005TheTI,
  title={The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria.},
  author={Carolina C P Mendes and Dawidson Assis Gomes and Mayerson Thompson and Natalia C Souto and T{\'e}rcio S Goes and Alfredo de Miranda G{\'o}es and Michele Angela Rodrigues and M Victoria Gomez and Michael H. Nathanson and Maria de F{\'a}tima M. P. Leite},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 49},
  pages={40892-900}
}
There are three isoforms of the inositol 1,4,5- trisphosphate receptor (InsP(3)R), each of which has a distinct effect on Ca(2+) signaling. However, it is not known whether each isoform similarly plays a distinct role in the activation of Ca(2+)-mediated events. To investigate this question, we examined the effects of each InsP(3)R isoform on transmission of Ca(2+) signals to mitochondria and induction of apoptosis. Each isoform was selectively silenced using isoform-specific small interfering… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 91 extracted citations

Similar Papers

Loading similar papers…