The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels.

@article{LpezCastejn2007TheTI,
  title={The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels.},
  author={Gloria L{\'o}pez-Castej{\'o}n and Mar{\'i}a Pilar Sepulcre and Francisco J. Roca and Barbara Castellana and Josep V Planas and Jose Jaime Meseguer and Victoriano Mulero},
  journal={Molecular immunology},
  year={2007},
  volume={44 10},
  pages={2772-80}
}
Interleukin-1beta (IL-1beta) is the prototypic pro-inflammatory cytokine. All the biological effects of IL-1beta are mediated through interaction with type 1 IL-1 receptor (IL-1RI), whereas another receptor, called type 2 IL-1R (IL-1RII), lacks an intracellular signalling domain and acts as a decoy receptor that down-regulates responses to IL-1beta. Although both receptors are present in bony fish, their expression and biological role in the regulation of IL-1beta activity in non-mammalian… CONTINUE READING