The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.

@article{Lang1998TheTI,
  title={The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.},
  author={Detlef Lang and Juergen Knop and Holger Wesche and Ute Raffetseder and Roland Kurrle and Diana Boraschi and Michael Uwe Martin},
  journal={Journal of immunology},
  year={1998},
  volume={161 12},
  pages={6871-7}
}
IL-1 binds to two types of receptors on the cell membrane, of which only type I (IL-1RI) transduces signals in concert with the coreceptor IL-1 receptor accessory protein (IL-1RAcP) while type II (IL-1RII) allegedly functions solely as ligand sink and decoy receptor without participating in IL-1 signaling. To investigate the regulatory role of IL-1RII on IL-1 responsiveness, a chimeric receptor encompassing the extracellular and transmembrane portions of IL-1RII and the cytoplasmic signal… CONTINUE READING

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