The type I membrane protein EFF-1 is essential for developmental cell fusion.

@article{Mohler2002TheTI,
  title={The type I membrane protein EFF-1 is essential for developmental cell fusion.},
  author={William Mohler and Gidi Shemer and Jacob J. del Campo and Clari Valansi and Eugene Opoku-Serebuoh and Victoria Scranton and Nirit Assaf and John White and Benjamin Podbilewicz},
  journal={Developmental cell},
  year={2002},
  volume={2 3},
  pages={355-62}
}
Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expressed as cells acquire fusion competence and encodes a novel integral membrane protein. EFF-1 sequence motifs suggest physicochemical actions that could cause adjacent bilayers to… CONTINUE READING

From This Paper

Topics from this paper.
97 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 97 extracted citations

Similar Papers

Loading similar papers…