The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

  title={The type I TGF-$\beta$ receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner},
  author={Alessandro Sorrentino and Noopur Thakur and Susanne Grimsby and Anders Marcusson and Verena von Bulow and Norbert Schuster and Shouting Zhang and Carl-Henrik Heldin and Mar{\'e}ne Landstr{\"o}m},
  journal={Nature Cell Biology},
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-β signals through its Type II and Type I receptors (TβRII and TβRI) causing phosphorylation of Smad proteins. TGF-β-associated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, was originally identified as an effector of TGF-β-induced p38 activation. However, the… 

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Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation

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Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

Examination of the role of TAK1 and TAB1 in the dorsoventral patterning of early Xenopus embryos suggests that xTAK1 and xTAB1 function in the BMP signal transduction pathway in xenopus embryos in a cooperative manner.

Structural basis for the interaction of TAK1 kinase with its activating protein TAB1.