The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

@article{Sorrentino2008TheTI,
  title={The type I TGF-$\beta$ receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner},
  author={Alessandro Sorrentino and Noopur Thakur and Susanne Grimsby and Anders Marcusson and Verena von Bulow and Norbert Schuster and Shouting Zhang and Carl-Henrik Heldin and Mar{\'e}ne Landstr{\"o}m},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={1199-1207}
}
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-β signals through its Type II and Type I receptors (TβRII and TβRI) causing phosphorylation of Smad proteins. TGF-β-associated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, was originally identified as an effector of TGF-β-induced p38 activation. However, the… 

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