The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb.

@article{Yi2000TheTI,
  title={The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb.},
  author={Soyun E Yi and Aaron Daluiski and Rebecca Pederson and Vicki Rosen and Karen M Lyons},
  journal={Development},
  year={2000},
  volume={127 3},
  pages={621-30}
}
Mice carrying a targeted disruption of BmprIB were generated by homologous recombination in embryonic stem cells. BmprIB(-/-) mice are viable and, in spite of the widespread expression of BMPRIB throughout the developing skeleton, exhibit defects that are largely restricted to the appendicular skeleton. Using molecular markers, we show that the initial formation of the digital rays occurs normally in null mutants, but proliferation of prechondrogenic cells and chondrocyte differentiation in the… CONTINUE READING
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