The type-4 pilus is the major virulence-associated adhesin of Pseudomonas aeruginosa--a review.

@article{Hahn1997TheTP,
  title={The type-4 pilus is the major virulence-associated adhesin of Pseudomonas aeruginosa--a review.},
  author={Heinz Hahn},
  journal={Gene},
  year={1997},
  volume={192 1},
  pages={99-108}
}
Pseudomonas aeruginosa (Pa) produces several surface-associated adherence factors or adhesins which promote attachment to epithelial cells and contribute to the virulence of this pathogen. Among them, the type-4 pilus accounts for about 90% of the adherence capability of Pa to human lung pneumocyte A549 cells. Furthermore, it is responsible for more than 90% of the virulence in AB.Y/SnJ mice. Pa type-4 pili display a tip-base differentiation with the adherence function located at the tip of the… CONTINUE READING
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