The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor.

@article{Murray1999TheT2,
  title={The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor.},
  author={Michael Van Murray and Ryuji Kobayashi and Adrian R. Krainer},
  journal={Genes & development},
  year={1999},
  volume={13 1},
  pages={
          87-97
        }
}
To identify activities involved in human pre-mRNA splicing, we have developed a procedure to separate HeLa cell nuclear extract into five complementing fractions. An activity called SCF1 was purified from one of these fractions by assaying for reconstitution of splicing in the presence of the remaining four fractions. A component of SCF1 is shown to be PP2Cgamma, a type 2C Ser/Thr phosphatase of previously unknown function. Previous work suggested that dephosphorylation of splicing factors may… CONTINUE READING
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