The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse.

@article{Street1997TheT1,
  title={The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse.},
  author={Valerie A. Street and Martha M. Bosma and Vasiliki Demas and Melissa R. Regan and Dean D Lin and Lucy C Robinson and William S. Agnew and Bruce L. Tempel},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 2},
  pages={635-45}
}
The opisthotonos (opt) mutation arose spontaneously in a C57BL/Ks-db2J colony and is the only known, naturally occurring allele of opt. This mutant mouse was first identified based on its ataxic and convulsive phenotype. Genetic and molecular data presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, which serves as an IP3-gated channel to release calcium from intracellular stores, is altered in the opt mutant. A genomic deletion in the IP3R1 gene… CONTINUE READING
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Expression and characterization of two alternatively spliced isoforms of rat type 1 receptor for inositol 1,4,5-trisphosphate

  • DD Lin
  • 1995
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