The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

@article{Zong2009TheTC,
  title={The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores},
  author={Xiangang Zong and Michael Schieder and Hartmut Cuny and Stefanie Fenske and Christian Gruner and Katrin R{\"o}tzer and Oliver Griesbeck and Hartmann Harz and Martin Biel and Christian A. Wahl-Schott},
  journal={Pflugers Archiv },
  year={2009},
  volume={458},
  pages={891 - 899}
}
Second messenger-induced Ca2+-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP3), Ca2+, and cyclic ADP ribose (cADPR) that trigger Ca2+-release from the endoplasmatic reticulum (ER), nicotinic acid adenine dinucleotide phosphate (NAADP) has been identified as a cellular metabolite that mediates Ca2+-release from lysosomal stores. While NAADP-induced Ca2+-release has been found in many tissues and cell… CONTINUE READING
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IP 3 receptor / Ca 2 + channel : from discovery to new signaling concepts

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