The two poles of the lymphocyte: specialized cell compartments for migration and recruitment.

@article{Pozo1998TheTP,
  title={The two poles of the lymphocyte: specialized cell compartments for migration and recruitment.},
  author={Miguel Angel Del Pozo and Marta Guerrero Nieto and Juan M Serrador and David de Sancho and Miguel Vicente-Manzanares and Carlos Martinez and Francisco S{\'a}nchez-Madrid},
  journal={Cell adhesion and communication},
  year={1998},
  volume={6 2-3},
  pages={125-33}
}
Chemotaxis, the directed migration of leukocytes towards a chemoattractant gradient, is a key phenomenon in the immune response. During lymphocyte-endothelial and -extracellular matrix interactions, chemokines induce the polarization of T lymphocytes, with generation of specialized cell compartments. The chemokine receptors involved in detection of the chemoattractant gradients concentrate at the leading edge (advancing front or anterior pole) of the cell. The adhesion molecules ICAM-1, -3… CONTINUE READING

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