The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.

@article{Andoniou1996TheTM,
  title={The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.},
  author={Christopher E Andoniou and Christine B. F. Thien and Wallace Y Langdon},
  journal={Oncogene},
  year={1996},
  volume={12 9},
  pages={1981-9}
}
We recently found that the 120-kD protein product of the c-cbl oncogene is tyrosine phosphorylated in tumor cells generated by bcr-abl or v-abl and that p120cbl will associate with these proteins in vivo. We also found an oncogenic form of cbl protein in the 70Z/3 pre-B cell lymphoma which exhibits deregulated tyrosine phosphorylation. These findings have led us to broaden our study of cbl's involvement in abl-mediated tumorigenesis. Here we show by immunodepletion that cbl is the major 120-kD… CONTINUE READING

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