The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics.

@article{Vogt1991TheTI,
  title={The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics.},
  author={Bruno Vogt and Jos{\'e} Mar{\'i}a Carrascosa and B. Ermel and Axel Ullrich and H. U. H{\"a}ring},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={177 3},
  pages={1013-8}
}
Human insulin receptor (HIR) is expressed in two isoforms which differ in the C-terminal end of the alpha-subunit (HIR-A = -12 aa, HIR-B = +12 aa). We studied internalization kinetics of HIR-A and HIR-B in Rat1 fibroblasts. Internalized receptors were quantified by 125I-insulin binding after cell trypsinisation and solubilization, surface receptors were determined by 125I-insulin binding to intact cells and by chemical crosslinking with B26-125I-insulin. HIR-A and HIR-B show different kinetics… CONTINUE READING

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