The two hats of SOS.

  title={The two hats of SOS.},
  author={Anjaruwee S. Nimnual and Dafna Bar-Sagi},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2002 145},
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be recruited to different cellular locations through interactions with the adaptor proteins Grb2 and E3b1. 
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