The two faces of Eve: dopamine's modulation of wakefulness and sleep.

@article{Rye2004TheTF,
  title={The two faces of Eve: dopamine's modulation of wakefulness and sleep.},
  author={David B. Rye},
  journal={Neurology},
  year={2004},
  volume={63 8 Suppl 3},
  pages={S2-7}
}
In Parkinson's disease (PD), waking is frequently punctuated by sleep episodes, including rapid eye movement (REM) (i.e., dream) sleep, and sleep is interrupted by motor activities such as periodic limb movements and REM sleep behavior disorder. Because these pathologic behaviors are unaccounted for by contemporary models, this review summarizes the complex effects of dopamine (DA) on normal and pathological waking-sleeping. Maintenance of wakefulness is probably promoted by mesocorticolimbic… CONTINUE READING

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