The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism

@article{Aravind2003TheTF,
  title={The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism},
  author={L. Aravind and Lakshminarayan M. Iyer and Vivek Anantharaman},
  journal={Genome Biology},
  year={2003},
  volume={4},
  pages={R64 - R64}
}
BackgroundThere is considerable heterogeneity in the phyletic patterns of major chromosomal DNA-binding proteins in archaea. Alba is a well-characterized chromosomal protein from the crenarchaeal genus Sulfolobus. While Alba has been detected in most archaea and some eukaryotic taxa, its exact functions in these taxa are not clear. Here we use comparative genomics and sequence profile analysis to predict potential alternative functions of the Alba proteins.ResultsUsing sequence-profile searches… 
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The Alba protein family: Structure and function.
TLDR
An overview of the Alba family proteins, their salient features and emphasize their functional role in different organisms reported so far are presented.
Archaeal chromatin proteins
TLDR
Investigation of archaeal chromatin proteins will lead to a better understanding of chromosomal organization and gene expression in Archaea and provide valuable information on the evolution of DNA packaging in cellular life.
Structural and evolutionary analysis of Leishmania Alba proteins.
TLDR
This work used homology modeling, protein-protein docking, and molecular dynamics simulations to explore the details of the Alba1-Alba3-RNA complex from Leishmania infantum at the molecular level and suggests that the RGG-box motif of LiAlba1 is important for protein function and stability.
The archaeal Sac10b protein family: conserved proteins with divergent functions.
TLDR
The present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea, is reviewed and existing and new X-ray and NMR structures of individual hyperthermophilic Sac10B proteins may represent very good models for introducing thermostability especially in enzymes for industrial use.
The CRM domain: an RNA binding module derived from an ancient ribosome-associated protein.
TLDR
It is suggested that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes.
Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding.
TLDR
A crystal structure of the human Rpp20/Rpp25 heterodimer is presented and it is proposed, using comparative structural analyses, that the evolutionary divergence of the single-stranded and helical nucleic acid binding specificities of eukaryotic Rpp 20/ Rpp25 and their related archaeal Alba chromatin protein dimers originate primarily from quaternary level differences observed in theirheterodimerization interface.
PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites
TLDR
It is demonstrated for the first time in eukaryotes that Alba-like proteins bind to both DNA and RNA and that their intracellular location is developmentally regulated.
Of proteins and RNA: the RNase P/MRP family.
TLDR
Current information on RNase P and the closely related universal eukaryotic enzyme RNase MRP are reviewed, focusing on their functions and structural organization.
The function of KptA/Tpt1 gene - a minor review.
TLDR
The gene structure, the evolution history and the function of KptA/Tpt1 from prokaryote to eukaryote organisms is concluded, and some proposals to clarify unclear problems of it in the future are given.
Alba-Domain Proteins of Trypanosoma brucei Are Cytoplasmic RNA-Binding Proteins That Interact with the Translation Machinery
TLDR
The identification of 3 Alba-domain proteins is consistent with stage-specific regulation of translation in trypanosomes, but most likely in the context of initiation.
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