The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism

@article{Aravind2003TheTF,
  title={The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism},
  author={L. Aravind and Lakshminarayan M. Iyer and Vivek Anantharaman},
  journal={Genome Biology},
  year={2003},
  volume={4},
  pages={R64 - R64}
}
BackgroundThere is considerable heterogeneity in the phyletic patterns of major chromosomal DNA-binding proteins in archaea. Alba is a well-characterized chromosomal protein from the crenarchaeal genus Sulfolobus. While Alba has been detected in most archaea and some eukaryotic taxa, its exact functions in these taxa are not clear. Here we use comparative genomics and sequence profile analysis to predict potential alternative functions of the Alba proteins.ResultsUsing sequence-profile searches… 
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An overview of the Alba family proteins, their salient features and emphasize their functional role in different organisms reported so far are presented.
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Current information on RNase P and the closely related universal eukaryotic enzyme RNase MRP are reviewed, focusing on their functions and structural organization.
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Alba-Domain Proteins of Trypanosoma brucei Are Cytoplasmic RNA-Binding Proteins That Interact with the Translation Machinery
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The identification of 3 Alba-domain proteins is consistent with stage-specific regulation of translation in trypanosomes, but most likely in the context of initiation.
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