The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread.

@article{Smith1995TheTD,
  title={The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread.},
  author={Gregory A Smith and H{\'e}l{\`e}ne Marquis and Susan E Jones and Norah C. Johnston and Daniel A Portnoy and Howard Goldfine},
  journal={Infection and immunity},
  year={1995},
  volume={63 11},
  pages={4231-7}
}
Listeria monocytogenes secretes two distinct phospholipases C, a phosphatidylinositol-specific phospholipase C (PI-PLC) and a broad-range phospholipase C (PC-PLC). In this study, single in-frame deletion mutants with mutations in each PLC and a double mutant lacking both PLCs were characterized with regard to virulence in mice, escape from a primary vacuole, and cell-to-cell spread in cell culture. The mutant lacking PI-PLC, previously shown to be twofold less virulent than the wild type in… CONTINUE READING
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