The two different receptors for tumor necrosis factor mediate distinct cellular responses.

@article{Tartaglia1991TheTD,
  title={The two different receptors for tumor necrosis factor mediate distinct cellular responses.},
  author={Louis A. Tartaglia and Rosemarie Weber and Irene Figari and C Partrik Reynolds and Michael A Palladino and David V. Goeddel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 20},
  pages={9292-6}
}
The individual roles of the murine type 1 and type 2 tumor necrosis factor (TNF) receptors (TNF-R1 and TNF-R2) were investigated utilizing (i) the strong species specificity of TNF-R2 for murine TNF compared to human TNF and (ii) agonistic rabbit polyclonal antibodies directed against the individual TNF receptors. Proliferation of mouse thymocytes and the murine cytotoxic T-cell line CT-6 is stimulated by murine TNF but not by human TNF. Consistent with this observation, polyclonal antibodies… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS