The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.

@article{Glover2007TheTR,
  title={The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.},
  author={Robert T. Glover and Jordan Kriakov and Scott J. Garforth and Anthony D Baughn and William Robert Jacobs},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 15},
  pages={5495-503}
}
Phosphate import is required for the growth of mycobacteria and is regulated by environmental inorganic phosphate (P(i)) concentrations, although the mechanism of this regulation has not been characterized. The expression of genes involved in P(i) acquisition is frequently regulated by two-component regulatory systems (2CRs) consisting of a sensor histidine kinase and a DNA-binding response regulator. In this work, we have identified the senX3-regX3 2CR as a P(i)-dependent regulator of genes… CONTINUE READING

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