The two-chain coiled-coil molecule of native epidermal keratin intermediate filaments is a type I-type II heterodimer.

@article{Steinert1990TheTC,
  title={The two-chain coiled-coil molecule of native epidermal keratin intermediate filaments is a type I-type II heterodimer.},
  author={Peter M. Steinert},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 15},
  pages={8766-74}
}
The composition of the two-chain coiled-coil molecule of murine epidermal keratin intermediate filaments (KIF) containing keratins 1 (type II) and 10 (type I) has been explored using native-type KIF as well as KIF reassembled in vitro from protein dissolved in urea solutions or from mixtures of 3H-labeled and unlabeled purified chains. By use of cross-linking, high resolution polyacrylamide gel electrophoresis and blotting for 3H-labeled keratins or with an anti-mouse keratin 10 antibody, it… CONTINUE READING

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