The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.

@article{Schubert1996TheTB,
  title={The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.},
  author={Ulrich Schubert and Stephan Bour and Antonio V. Ferrer-Montiel and Mauricio Montal and F Maldarell and Klaus Strebel},
  journal={Journal of virology},
  year={1996},
  volume={70 2},
  pages={809-19}
}
The human immunodeficiency virus type 1 (HIV-1) Vpu protein is an integral membrane phosphoprotein that induces CD4 degradation in the endoplasmic reticulum and enhances virus release from the cell surface. CD4 degradation is specific, requires phosphorylation of Vpu, and involves the interaction between Vpu and the CD4 cytoplasmic domain. In contrast… CONTINUE READING