The two CD23 isoforms display differential regulation in chronic lymphocytic leukaemia.

@article{Fournier1995TheTC,
  title={The two CD23 isoforms display differential regulation in chronic lymphocytic leukaemia.},
  author={Sylvie M Fournier and Liang Yang and Guy J. Delespesse and M. Luz Rubio and Guy Biron and Marika Sarfati},
  journal={British journal of haematology},
  year={1995},
  volume={89 2},
  pages={373-9}
}
B lymphocytes from chronic lymphocytic leukaemia (B-CLL) patients express the two CD23 isoforms (type A and B), which differ only in their intracytoplasmic domain. The abnormal regulation of the CD23 antigen in response to IL-4, IFNs alpha and gamma results in CD23 over-expression on B-CLL cells. Our present study shows that the two CD23 isoforms are differentially and abnormally regulated on B-CLL cells. IL-4 selectively up-regulates CD23 type A mRNA in five different B-CLL patients, whereas… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…