The twitcher mouse: degeneration of oligodendrocytes in vitro.

  title={The twitcher mouse: degeneration of oligodendrocytes in vitro.},
  author={Hitoshi Nagara and Hideoki Ogawa and Yoshihiro Sato and Tohru Kobayashi and Koichi Suzuki},
  journal={Brain research},
  volume={391 1},
Oligodendrocytes were isolated from the brain of the twitcher (twi/twi), an authentic murine model of globoid cell leukodystrophy (GLD), carrier (+/twi) and their littermate controls (+/+) and were maintained in vitro for 24 days. By 4 days in vitro (4 DIV) oligodendrocytes developed thorny processes and their morphology were closely similar to each other regardless of their genetic status. After 17 DIV, however, oligodendrocytes in twi/twi progressively degenerated and only 12% of… CONTINUE READING

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