The twisted 'life' of DNA in the cell: bacterial topoisomerases.

  title={The twisted 'life' of DNA in the cell: bacterial topoisomerases.},
  author={A Luttinger},
  journal={Molecular microbiology},
  volume={15 4},
DNA topoisomerases are essential to the cell for the regulation of DNA supercoiling levels and for chromosome decatenation. The proposed mechanisms for these reactions are essentially the same, except that a change in supercoiling is due to an intramolecular event, while decatenation requires an intermolecular event. The characterized bacterial topoisomerases appear capable of both types of reaction in vitro. Four DNA topoisomerases have been identified in Escherichia coli. Topoisomerase I… CONTINUE READING

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