The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site.

Abstract

The effect of [CO] on acetyl-CoA synthesis activity of the isolated alpha subunit of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase from Moorella thermoacetica was determined. In contrast to the complete alpha(2)beta(2) enzyme where multiple CO molecules exhibit strong cooperative inhibition, alpha was weakly inhibited, apparently by a single CO… (More)

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Cite this paper

@article{Tan2005TheTO, title={The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site.}, author={Xiangshi Tan and H. Y. Loke and Shawn B Fitch and Paul A. Lindahl}, journal={Journal of the American Chemical Society}, year={2005}, volume={127 16}, pages={5833-9} }