The tumourigenicity of iPS cells and their differentiated derivates

  title={The tumourigenicity of iPS cells and their differentiated derivates},
  author={Zhiqiang Liu and Yu Tang and Shuanghong L{\"u} and Jin Zhou and Zhi-yan Du and Cuimi Duan and ZhiYan Li and Changyong Wang},
  booktitle={Journal of cellular and molecular medicine},
Induced pluripotent stem cell (iPSC) provides a promising seeding cell for regenerative medicine. However, iPSC has the potential to form teratomas after transplantation. Therefore, it is necessary to evaluate the tumorigenic risks of iPSC and all its differentiated derivates prior to use in a clinical setting. Here, murine iPSCs were transduced with dual reporter gene consisting of monomeric red fluorescent protein (mRFP) and firefly luciferase (Fluc). Undifferentiated iPSCs, iPSC derivates… CONTINUE READING
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