The tumourigenic and carcinogenic effect of 12-0-tetradecanoylphorbol-13-acetate when applied to the skin of BALB/cA and hairless (hr/hr) mice.

Abstract

One hundred and fourteen BALB/cA and 89 hairless (hr/hr, Oslo strain) mice of both sexes were treated topically once a week on the dorsal skin for about 17 months with 18 nmol 12-0-tetradecanoylphorbol-13-acetate (TPA) in 0.2 ml acetone or with 0.2 ml acetone alone, and observed for up to 24 months. At autopsy all visible lesions and selected areas from the… (More)

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