The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.

Abstract

The tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10; a phosphatidylinositol 3-phosphatase) is a multifunctional protein deregulated in many types of cancer. It is suggested that a number of proteins that relate with PTEN functionally or physically have not yet been found. In order to search for PTEN-interacting proteins… (More)
DOI: 10.1042/BJ20071403

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