The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4.

@article{Troost2012TheTS,
  title={The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4.},
  author={Tobias Felix Troost and Sandra Teixeira Jaeckel and Nadja Ohlenhard and Thomas W. Klein},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 3},
  pages={
          763-76
        }
}
Recent work indicates that defects in late phases of the endosomal pathway caused by loss of function of the tumour suppressor gene lethal (2) giant discs (lgd) or the function of the ESCRT complexes I-III result in the ligand-independent activation of the Notch pathway in all imaginal disc cells in Drosophila melanogaster. lgd encodes a member of an uncharacterised protein family, whose members contain one C2 domain and four repeats of the DM14 domain. The function of the DM14 domain is… CONTINUE READING

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