The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma.

@article{Matsuoka2015TheTS,
  title={The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma.},
  author={Yuichiro Matsuoka and Ryoji Yoshida and Hideki Nakayama and Masashi Nagata and Akiyuki Hirosue and Takuya Tanaka and Kenta Kawahara and Yoshihiro Nakagawa and Jyunki Sakata and Hidetaka Arita and Akimitsu Hiraki and Masanori Shinohara},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2015},
  volume={123 3},
  pages={205-14}
}
It has been increasingly recognized that the tumour microenvironment is a critical factor involved in cancer progression. However, little is known about the clinical value of the stromal features in oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the clinical significance of cancer-associated fibroblasts (CAFs) and tumour-associated macrophages (TAMs) in OSCC. OSCC specimens were obtained from 60 patients who underwent surgery following 5-fluorouracil-based… CONTINUE READING
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