The tumorigenicity of diploid and aneuploid human pluripotent stem cells.

@article{Blum2009TheTO,
  title={The tumorigenicity of diploid and aneuploid human pluripotent stem cells.},
  author={Barak Blum and Nissim Benvenisty},
  journal={Cell cycle},
  year={2009},
  volume={8 23},
  pages={3822-30}
}
Human embryonic stem cells (HESCs) and induced pluripotent stem cells (HiPSCs) offer an immense potential as a source of cells for regenerative medicine. However, the ability of undifferentiated HESCs and HiPSCs to produce tumors in vivo presents a major obstacle for the translation of this potential into clinical reality. Therefore, characterizing the nature of HESC- and HiPSC-derived tumors, especially their malignant potential, is extremely important in order to evaluate the risk involved in… CONTINUE READING

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