The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment

@article{Rolny2008TheTS,
  title={The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment},
  author={Charlotte Rolny and Lorena Capparuccia and Andrea Casazza and Massimiliano Mazzone and Antonella Vallario and Alessandro Cignetti and Enzo Medico and Peter Carmeliet and Paolo Maria Comoglio and Luca Tamagnone},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={1155 - 1171}
}
Semaphorins are a large family of evolutionarily conserved morphogenetic molecules originally identified for their repelling role in axonal guidance. Intriguingly, semaphorins have recently been implicated in cancer progression (Neufeld, G., T. Lange, A. Varshavsky, and O. Kessler. 2007. Adv. Exp. Med. Biol. 600:118-131). In particular, semaphorin 3B (SEMA3B) is considered a putative tumor suppressor, and yet we found that it is expressed at high levels in many invasive and metastatic human… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

The role of the cell–cell interactions in cancer progression

Journal of cellular and molecular medicine • 2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…