The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

@article{Heppner2001TheTS,
  title={The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.},
  author={Christina Heppner and Karl Bilimoria and Sunita Agarwal and Mary Beth Kester and Leslie J Whitty and Siradanahalli C. Guru and Settara C Chandrasekharappa and Francis S. Collins and Allen M. Spiegel and Stephen J. Marx and A. Lee Burns},
  journal={Oncogene},
  year={2001},
  volume={20 36},
  pages={4917-25}
}
Multiple endocrine neoplasia type 1 is an autosomal dominant tumor syndrome. Manifestations include neoplasms of the parathyroid glands, enteropancreatic neuroendocrine cells, and the anterior pituitary gland. The MEN1 tumor suppressor gene encodes menin, a 610 amino acid nuclear protein without sequence homology to other proteins. To elucidate menin function, we used immunoprecipitation to identify interacting proteins. The NF-kappaB proteins p50, p52 and p65 were found to interact… CONTINUE READING