The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma

Abstract

Oncogenic activation of the NF-κB signaling pathway is common in hepatocellular carcinoma (HCC). However, the molecular mechanisms remain largely unexplored. Previous studies have demonstrated that menin, a tumor suppressor protein, could interact with NF-κB protein and repress p65-mediated transcriptional activation. In the present study, we found that… (More)
DOI: 10.1007/s11033-012-2326-0

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