The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells.

@article{Zhu2005TheTS,
  title={The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells.},
  author={Jin-Jun Zhu and Fo-bao Li and Jun-min Zhou and Zong-chao Liu and Xiaofeng Zhu and Wei-ming Liao},
  journal={Cancer biology & therapy},
  year={2005},
  volume={4 1},
  pages={39-47}
}
p33ING1b can stimulate cell cycle arrest, DNA repair, apoptosis and chemosensitivity. The actions of p33ING1b involve p53-dependent and p53-independent mechanisms. To investigate if the p33ING1b isoform is involved in the chemosensitivity of osteosarcoma cells, p33ING1b was overexpressed in p53+/+ U2OS cells or p53-mutant MG63 cells, and then cell growth arrest and apoptosis were assessed after treatment with taxol. The results showed that p33ING1b markedly increased taxol-induced growth… CONTINUE READING

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