The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways

@article{Shapira2007TheTS,
  title={The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways},
  author={Saar Shapira and Batya Barkan and Elena Friedman and Yoel Kloog and Reuven Stein},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={1070-1070}
}
Neurofibromatosis type 1 (NF1) is characterized by a high incidence of benign and malignant tumors attributed to loss of function of Nf1, which encodes neurofibromin, a tumor suppressor with Ras-GAP activity. Neurofibromin deficiency typically causes chronic activation of Ras, considered the major contributor to manifestation of NF1. Resistance to radio- and chemotherapy are typical of NF1-associated tumors, but the underlying mechanism is unknown. Here, we investigated interrelationships… CONTINUE READING

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